Bill Cassidy, Louisiana’s incumbent Republican senator, has been in Donald Trump’s crosshairs since Cassidy voted to convict during the President’s impeachment trial in the wake of the January 6th attack on the U.S. Capitol. Trump has accused Cassidy, a physician by training, of being “disloyal” for declining to support a MAHA-aligned nominee for Surgeon General. Cassidy has also repeatedly clashed with the Secretary of Health and Human Services, Robert F. Kennedy, Jr., over his attempts to overhaul the Centers for Disease Control and Prevention and to reduce federal vaccine recommendations.

Election 2026
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Trump has endorsed Representative Julia Letlow, calling her a “TOTAL WINNER.” Letlow’s husband, Luke Letlow, was elected to Congress in 2020, but he died of COVID-19 shortly before he was able to take office; Letlow, a former academic administrator, won the special election to fill his seat. Cassidy’s other challenger is John Fleming, the Louisiana state treasurer, who served as a White House deputy chief of staff during the first Trump term. Fleming has accused Letlow’s campaign chair, Ralph Abraham, of offering him a position as deputy director of the C.D.C. in return for dropping out of the race; Abraham has denied the accusation.

On the Democratic side, Nick Albares, a nonprofit executive who previously served as a policy adviser to John Bel Edwards, the Democratic former governor, is facing off against Gary Crockett, a retired Navy veteran who has stressed the need for “practical” leadership, and Jamie Davis, Jr., a third-generation Louisiana farmer who has emphasized progressive issues, including raising the minimum wage, taxing the wealthy, and passing Medicare for All.

Primary elections for the state’s House races were scheduled for Saturday, but were suspended after the Supreme Court’s ruling in Louisiana v. Callais, a landmark decision finding that lawmakers had illegally used racial demographics to redraw congressional districts in 2024. The decision, which was issued last month, torpedoed a core provision in the Voting Rights Act and allowed Southern states to quickly redraw congressional maps to excise majority-minority districts, in which racial minorities make up more than fifty per cent of the population. Earlier this week, Louisiana’s state Senate voted to advance a new congressional map that would eliminate one of the state’s two Black-majority congressional districts, likely giving the G.O.P. an extra seat in the 2026 midterms.